DBCO-Dap(m-PEG4)-Val-Cit-PAB(m-PEG4)-MMAE Pomalidomide 722 SMILES: [O-]C(=O)C1=CC=C(C=C1C1=C2C=C3CCC[N+]4=C3C(CCC4)=C2OC2=C3CCCN4CCCC(C=C12)=C34)C(=O)NCCCN=[N]#N Purity (HPLC):

722 SMILES: [O-]C(=O)C1=CC=C(C=C1C1=C2C=C3CCC[N+]4=C3C(CCC4)=C2OC2=C3CCCN4CCCC(C=C12)=C34)C(=O)NCCCN=[N]#N Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

474 SMILES [N-]=[N+]=NCCOCCOCCOCCNC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

CA-DBCO can be used to attach DBCO moiety to protein

Product Name Thalidomide-5'-propargyl-PEG3-OH Synonyms CAS Number n/a Related CAS Molecular Formula C22H24N2O8 Molecular Weight 444

Product Name Thalidomide-5'-O-PEG5-OH Synonyms CAS Number n/a Related CAS Molecular Formula C23H30N2O10 Molecular Weight 494

DBCO-Dap(m-PEG4)-Val-Cit-PAB(m-PEG4)-MMAE Pomalidomide 722 SMILES: [O-]C(=O)C1=CC=C(C=C1C1=C2C=C3CCC[N+]4=C3C(CCC4)=C2OC2=C3CCCN4CCCC(C=C12)=C34)C(=O)NCCCN=[N]#N Purity (HPLC):SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a DBCO Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further