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Achieving In Vivo Target Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders
[O-]C(=O)C1=CC(=CC=C1C1=C2C=C3CCC[N+]4=C3C(CCC4)=C2OC2=C3CCCN4CCCC(C=C12)=C34)C(=O)NCCCN=[N]#N Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only
87 SMILES: NCCCCCNS(=O)(=O)C1=CC=C(C(=C1)C1=C2C=C3CCC[N+]4=C3C(CCC4)=C2OC2=C3CCCN4CCCC(C=C12)=C34)S([O-])(=O)=O
Product Name BG-SS-SulfoCy5 Synonyms SNAP-SS-SulfoCynine 5 CAS Number Related CAS Molecular Formula C51H61N9O8S4 Molecular Weight 1056
Product Name: 5(6)-ROX Synonyms: 5-(and 6)-Carboxy-X-rhodamine CAS Number: 198978-94-5 Molecular Formula: C33H30N2O5 Molecular Weight: 534
DBCO-Lys(m-PEG4)-Val-Cit-PAB(m-PEG8)-PNP Size:100mg Achieving In Vivo Target DepletionSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a DBCO Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further
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