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It binds to the VHL E3 ligase with an IC50 of 0
915 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCOCCOCC#C)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
Product Name: Lenalidomide-CO-C1--piperazine HCl Synonyms: CAS Number: Molecular Formula: C19H25Cl2N5O4 Molecular Weight: 458
Product Name Lenalidomide-5'-CO-C3-alkyne Synonyms CAS Number n/a Related CAS Molecular Formula C19H19N3O4 Molecular Weight 353
Carmichael
Propargyl-Acetyl-Val-Cit-PAB(m-PEG8)-Exatecan Size:5mg It binds to the VHLSOLU KNEX cleavable linker features a Val Cit dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC
