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NRX-1532 acts as molecular glue in cells to promote the ubiquitylation and subsequent degradation of mutantbeta-catenin by the 26S proteasome
Product Name Phthalimidinoglutarimide-propargyl-C1-amine HCl Synonyms Phthalimidinoglutarimide-4'-propargyl-C1-amine HCl CAS Number 2138440-40-9 Related CAS Molecular Formula C17H18ClN3O3 Molecular Weight 347
1039/d4cb00209a
S)-AHPC-CO-C3-azide Synonyms CAS Number 2353496-85-0 Related CAS Molecular Formula C26H35N7O4S Molecular Weight 541
496 SMILES OCCOCCOCCOCCNC(=O)COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
Mal-Lys(m-PEG4)-Gly-Gly-Phe-Gly Size:100mg NRX-1532 acts as molecular glueSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. In this product, a Mal Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG, amine containing groups, or polysarcosine (PSAR), to enhance aqueous solubility. Solubility and physicochemical properties can be finely tuned
