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NCT02 is a molecular glue cyclin K degrader
Product Name Pomalidomide-CO-C5-Br Synonyms Pomalidomide-4'-CO-C5-Br CAS Number 2227423-38-1 Related CAS Molecular Formula C19H20BrN3O5 Molecular Weight 450
Product Name DOTA-tris(t-Bu)ester-heptyne Synonyms CAS Number n/a Related CAS Molecular Formula C35H63N5O7 Molecular Weight 665
Product Name tert-butyl N-(2-{2-[4-(4-aminobutyl)piperazin-1-yl]ethoxy}ethyl)carbamate Synonyms CAS Number n/a Related CAS Molecular Formula C17H36N4O3 Molecular Weight 344
Contains an E3 ligase ligand with alkyl linker and a terminal piperazine moiety
Mal-Acetyl-Dap(m-PEG4)-Val-Ala-PAB Size:100mg NCT02 is a molecular glueSOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a Mal Acetyl Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The Mal Acetyl group may also improve retro Michael addition stability during antibody conjugation. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG, amine containing groups, or polysarcosine
